2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W015224R
    Methyl 2-(1H-indol-3-yl)acetate (Standard) 1912-33-0 98%
    Methyl 2-(1H-indol-3-yl)acetate (Standard) is the analytical standard of Methyl 2-(1H-indol-3-yl)acetate. This product is intended for research and analytical applications. Methyl 2-(1H-indol-3-yl)acetate is an endogenous metabolite.
    Methyl 2-(1H-indol-3-yl)acetate (Standard)
  • HY-W015240R
    N-Acetyl-L-glutamic acid (Standard) 1188-37-0 98%
    N-Acetyl-L-glutamic acid (Standard) is the analytical standard of N-Acetyl-L-glutamic acid (HY-W015240). This product is intended for research and analytical applications. N-Acetyl-L-glutamic acid is a type of glutamic acid that can serve as a component of cell culture media. When combined with media containing inorganic salts, carbohydrates, vitamins, and amino acids, N-Acetyl-L-glutamic acid plays roles in promoting cell growth, enhancing antibody production, etc. N-Acetyl-L-glutamic acid is also an endogenous metabolite that can be found in the brain. Additionally, as an IgE blocker, N-Acetyl-L-glutamic acid can be used in the research of allergic diseases.
    N-Acetyl-L-glutamic acid (Standard)
  • HY-W015342R
    Methyl anisate (Standard) 121-98-2
    Methyl anisate (Standard) is the analytical standard of Methyl anisate. This product is intended for research and analytical applications. Methyl anisate is an endogenous metabolite.
    Methyl anisate (Standard)
  • HY-W015444R
    2-Hydroxyoctanoic acid (Standard) 617-73-2
    2-Hydroxyoctanoic acid (Standard) is the analytical standard of 2-Hydroxyoctanoic acid. This product is intended for research and analytical applications. 2-Hydroxyoctanoic acid is a medium chain acyl-CoA synthetase inhibitor with a Ki of 500 μM[1].
    2-Hydroxyoctanoic acid (Standard)
  • HY-W015464R
    N-Isovaleroylglycine (Standard) 16284-60-9 98%
    N-Isovaleroylglycine (Standard) is the analytical standard of N-Isovaleroylglycine. This product is intended for research and analytical applications. N-Isovaleroylglycine is an acyl glycine and could be used as a biomarker for the predispositon for weight gain and obesity.
    N-Isovaleroylglycine (Standard)
  • HY-W015464S
    N-Isovalerylglycine-d9 1330037-21-2 99.0%
    N-Isovalerylglycine-d9 is the deuterium labeled N-Isovaleroylglycine. N-Isovaleroylglycine is an acyl glycine and could be used as a biomarker for the predispositon for weight gain and obesity.
    N-Isovalerylglycine-d9
  • HY-W015618R
    2',4'-Dimethylacetophenone (Standard) 89-74-7 98%
    Nefopam (hydrochloride) (Standard) is the analytical standard of Nefopam (hydrochloride). This product is intended for research and analytical applications. Nefopam hydrochloride (Fenazoxine hydrochloride) is a centrally-acting but non-opioid analgesic drug, for the relief of moderate to severe pain. Nefopam hydrochloride targets β-catenin protein level in mesenchymal cells in-vitro and in-vivo.
    2',4'-Dimethylacetophenone (Standard)
  • HY-W015675R
    4-Hydroxycyclohexanecarboxylic acid (Standard) 17419-81-7
    Lasamide (Standard) is the analytical standard of Lasamide. This product is intended for research and analytical applications. Lasamide is a potent human Carbonic Anhydrase inhibitor with Ki values of 7.54 and 2.76 nM for hCAXII and hCAIX, respectively.
    4-Hydroxycyclohexanecarboxylic acid (Standard)
  • HY-W015780S
    1,4-Dimethoxybenzene-d10 74079-00-8 99.6%
    1,4-Dimethoxybenzene-d10 is the deuterium labeled 1,4-Dimethoxybenzene. 1,4-Dimethoxybenzene is an endogenous metabolite.
    1,4-Dimethoxybenzene-d10
  • HY-W015851R
    (R)-3-Hydroxybutanoic acid sodium (Standard) 13613-65-5
    (R)-3-Hydroxybutanoic acid (sodium) (Standard) is the analytical standard of (R)-3-Hydroxybutanoic acid (sodium). This product is intended for research and analytical applications. (R)-3-Hydroxybutanoic acid ((R)-3-Hydroxybutyric acid) sodium is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones[1][2].
    (R)-3-Hydroxybutanoic acid sodium (Standard)
  • HY-W015851S
    3-Hydroxybutanoic acid-13C sodium 1173022-79-1 98%
    3-Hydroxybutanoic acid-13C-13C (sodium) is the 13C labeled 3-Hydroxybutanoic acid sodium (HY-W010452). 3-Hydroxybutyric acid sodium (β-Hydroxybutyric acid sodium) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid sodium can modulate the properties of membrane lipids.
    3-Hydroxybutanoic acid-13C sodium
  • HY-W015874R
    2-Hydroxy-2-methylbutanoic acid (Standard) 3739-30-8
    2-Hydroxy-2-methylbutanoic acid (Standard) is the analytical standard of 2-Hydroxy-2-methylbutanoic acid. This product is intended for research and analytical applications. 2-Hydroxy-2-methylbutanoic acid, an unusual metabolite, is associated with 2-hydroxyglutaric aciduria and maple syrup urine disease.
    2-Hydroxy-2-methylbutanoic acid (Standard)
  • HY-W015878R
    5-Aminovaleric acid (Standard) 660-88-8 98%
    5-Aminovaleric acid (Standard) is the analytical standard of 5-Aminovaleric acid. This product is intended for research and analytical applications. 5-Aminovaleric acid is believed to act as a methylene homologue of gamma-aminobutyric acid (GABA) and functions as a weak GABA agonist.
    5-Aminovaleric acid (Standard)
  • HY-W015969R
    1-Aminopropan-2-ol (Standard) 78-96-6 98%
    1-Aminopropan-2-ol (Standard) is the analytical standard of 1-Aminopropan-2-ol. This product is intended for research and analytical applications. 1-Aminopropan-2-ol is a microbial metabolism of amino alcohol metabolism via propionaldehyde and acetaldehyde in a species of Pseudomonas.
    1-Aminopropan-2-ol (Standard)
  • HY-W016145S
    L-Glutamic acid-13C5 hydrate salt 202114-62-3 98%
    L-Glutamic acid-13C5 hydrate salt is the 13C labeled L-Glutamic acid hydrate salt. L-Glutamic acid monosodium hydrate is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid monosodium hydrate has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid monosodium hydrate can be used in the study of neurological diseases. L-Glutamic acid monosodium hydrate acts at ionotropic and?metabotropic glutamate receptors.
    L-Glutamic acid-13C5 hydrate salt
  • HY-W016409R
    Ethyl 3,4-dihydroxybenzoate (Standard) 3943-89-3 98%
    Ethyl 3,4-dihydroxybenzoate (Standard) (Protocatechuic acid ethyl ester (Standard)) is the analytical standard of Ethyl 3,4-dihydroxybenzoate (HY-W016409). This product is intended for research and analytical applications. Ethyl 3,4-dihydroxybenzoate (Protocatechuic acid ethyl ester) is an orally effective, blood-brain barrier-permeable, competitive prolyl hydroxylase (PHD) inhibitor that inhibits the hydroxylation modification of hypoxia-inducible factor (HIF) by PHD. Ethyl 3,4-dihydroxybenzoate stabilizes HIF-1α by inhibiting PHD, activates downstream pathways to induce autophagy and apoptosis of tumor cells, and regulates inflammatory responses, inhibits the NF-κB pathway, improves vascular permeability, and promotes osteoblast differentiation. Ethyl 3,4-dihydroxybenzoate has anti-tumor, anti-hypoxic injury, and bone metabolism regulation effects. It can also be used in the research of cardiovascular protection (such as reducing myocardial ischemic damage), bone tissue engineering (promoting osteogenesis/inhibiting osteoclast differentiation), and prevention and treatment of high-altitude cerebral edema.
    Ethyl 3,4-dihydroxybenzoate (Standard)
  • HY-W016628R
    L-Gulono-1,4-lactone (Standard) 1128-23-0
    L-Gulono-1,4-lactone (L-Gulonolactone) (Standard) is the analytical standard of L-Gulono-1,4-lactone. This product is intended for research and analytical applications. L-Gulono-1,4-lactone is a biosynthetic precursor of L-Ascorbic acid (Vitamin C) (HY-B0166). L-Gulono-1,4-lactone can be enzymatically converted to L-Ascorbic acid via the animal uronic acid pathway, while species such as humans lack the key oxidase that catalyzes this step, resulting in the disruption of this pathway and the necessity to obtain Vitamin C from diet. L-Gulono-1,4-lactone is a putative intermediate in an alternative biosynthetic pathway of L-Ascorbic acid in Arabidopsis thaliana.
    L-Gulono-1,4-lactone (Standard)
  • HY-W016647R
    For-Met-OH (Standard) 4289-98-9
    For-Met-OH (Standard) (N-Formylmethionine (Standard)) is the analytical standard of For-Met-OH (HY-W016647). This product is intended for research and analytical applications. For-Met-OH (N-Formylmethionine) can be involved in the translation process of bacteria, chloroplasts, and mitochondria. For-Met-OH plays different roles in different species and organelles, such as promoting the formation of protein complexes in mitochondria and acting as a degradation signal in bacteria and yeast. The level of For-Met-OH is closely related to certain diseases; for example, For-Met-OH is a potential biomarker for metabolic disorders and poor prognosis in critically ill patients.
    For-Met-OH (Standard)
  • HY-W016715R
    L-Cysteine hydrochloride hydrate (Standard) 7048-04-6
    L-Cysteine (hydrochloride hydrate) (Standard) is the analytical standard of L-Cysteine (hydrochloride hydrate). This product is intended for research and analytical applications. L-Cysteine hydrochloride hydrate is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride hydrate suppresses ghrelin and reduces appetite in rodents and humans.
    L-Cysteine hydrochloride hydrate (Standard)
  • HY-W016734R
    2-Amino-5-ureidopentanoic acid (Standard) 627-77-0 98%
    2-Amino-5-ureidopentanoic acid (Standard) is the analytical standard of 2-Amino-5-ureidopentanoic acid. This product is intended for research and analytical applications. 2-Amino-5-ureidopentanoic acid is an endogenous metabolite.
    2-Amino-5-ureidopentanoic acid (Standard)
Cat. No. Product Name / Synonyms Application Reactivity